EDUCATION:

1986-1993 Ph.D. Immunology,  University of Massachusetts Graduate School of Biomedical Sciences,                            Worcester, MA., Immunology Program, Dept. of Molecular Genetics and Microbiology.                             Dissertation:  "Regulation of IgA class switch recombination in the I.29µ B cell lymphoma                                                     by cytokines and inhibitors of poly(ADP-ribose) polymerase." 1979-1983  A.B. Biology, Bowdoin College, Brunswick, ME.

POSITIONS HELD:

2006-present  Associate Professor, Department of Biological Sciences                        Southeastern Louisiana University, Hammond, LA. 2000-2006     Assistant Professor, Department of Biological Sciences                         Southeastern Louisiana University, Hammond, LA. 1997-2000     Associate Research Scientist Section of Immunobiology,                         Yale University School of Medicine, New Haven, CT. 1993-1997     Postdoctoral Fellow, Section of Immunobiology,                         Yale University School of Medicine New Haven, CT. 1988-1993     Graduate Research Assistant Department of Molecular Genetics and Microbiology,                        University of Massachusetts Graduate School of Biomedical Sciences, Worcester, MA. 1983-1986     Laboratory Technician in Histocompatibility Testing Lab                         Massachusetts General Hospital, Boston, MA.

PROFESSIONAL EXPERIENCE

2000-present   Southeastern Louisiana University, Hammond, LA., Department of Biological Sciences.                           Current Projects:                                 -Studies of developmental timing/tissue distribution of aberrant and ectopic V(D)J                                   recombination events in vivo.                                 -Structure/function studies of Na+ channel slow inactivation by site-directed mutagenesis                                   (w/John O’Reilly, Ph.D.)                                 -Studies of exercise links to the immune system (w/Robert Kraemer, Ph.D.)   1997-2000        Yale University School of Medicine, New Haven, CT., Section of Immunobiology.                                -Molecular and biochemical studies of lymphocyte receptor variable region gene assembly in                                 vitro.  (w/David G. Schatz, Ph.D.) 1993-1997        Yale University School of Medicine, New Haven, CT., Section of Immunobiology.                                -Development of a system for inducible, tetracycline regulated gene expression in cultured                                   cells and transgenic mice.                                 -Application to studies of DNA recombination in developing lymphocytes.                                 (w/ David G. Schatz, Ph.D.) 1988-1993       University of Massachusetts Graduate School of Biomedical Sciences, Worcester, MA.,                           Department of Molecular Genetics and Microbiology.                                -Studies of the regulation of immunoglobulin heavy chain class switch recombination by                                cytokines and inhibitors of DNA repair.  (w/Janet Stavnezer, Ph.D.)    1983-1986       Massachusetts General Hospital, Boston, MA.,Histocombatibility Testing Lab.                               -Tissue matching for organ transplant and clinical immunology research.                                 (Director: Thomas C. Fuller, Ph.D.) 1982-1983     Bowdoin College, Brunswick, ME., Department of Biology.                              -Angiogenisis in chick liver development.  (Honors project w/Glenn K. Sherer, Ph.D.)

COURSES TAUGHT:

2000-present    Southeastern Louisiana University:          -Cell Biology:   (3 credit hrs., Fall and Spring Semesters)                                    Semester Course,, Sophomore Level.                                    Text: Albert’s et al., Essential Cell Biology: An Introduction to the Molecular Biology                                    of the Cell. 3rd Edition          -Immunology:  (4 credit hrs., Fall Semester)                                   Semester Course, Upper level undergraduate/graduate lecture with laboratory.                                   Text: Kuby Immunology, 6th Edition.          -Virology :       (4 credit hrs., Spring Semester)                                  Semester Course, Upper level undergraduate/graduate lecture w/seminar component.                                  Texts: Voyles, The Biology of Viruses, 2nd Edition; Shores, Understanding Viruses 2nd edition          -Advanced Immunology:  (1 credit, Spring 2011)                                  Graduate Seminar course involving readings/discussion relating to epigenetics and gene                                  rearrangement in the immune system..          -Biology Seminar:  (1 credit hr., Fall and Spring Semesters, previously)                                  A majors course in general and research-focused areas of biology and presentation methods                                  in biological sciences.  Text: Purves et al., Life: the Science of Biology, 6th Ed.          -Professional Aspects of Biology:  (1 credit hour, Fall Semester 05)                                  A majors course involving student attendance at seminars presented by individuals in                                  various professional fields related to biology.          -General Biology Laboratory I:  (1 credit hour).                                   TA Mentor for Jessica Mayfield (Fall 2004, Spring 2005)                                  TA Mentor for Jessica Chancey (Fall 2005)

Teaching Honors:  2005-Received student nomination for and was chosen for Who’s Who Among American Teachers.

STUDENTS:

Student Research Assistants (and subsequent positions):   -Undergraduates:                       Carl Gautier, pre-med, OSCAR student, biology major (Spring 2001-Spring 2002)                                (LSU Medical School)                       Dwayne Delrie, pre-med.student, chemistry major (Summer 2001-Spring 2002)                                (Tulane Medical School)                       Jason Eleser, OSCAR student, pre-med.student, biology major (Summer 2002-Spring 2003)                                (LSU Medical School)                       Amy Melancon, biology major, (Spring 2003), assisted Erica Perrer                                (Medical Technology Certification Program)                       Alicia Manuel, biology major (Fall 2003), assisted Catherine diBenedetto                                (SLU Graduate Program in biology)                       Daniel King, biology major (Fall 2003, Spring 2004), assisted Charles Nebel                                (Private Environmental Testing Lab)                       Jessica Sprague (Mayfield), biology major (Spring 2004),                                (SLU Graduate Program in biology)                       Chadney Glover, biology major (Summer 04), assisted Jessica Mayfield                                (SLU Graduate Program in biology)                       Jessica Chancey, OSCAR student, biology major (Fall 04, Spring 05)                                (SLU Graduate Program in biology)                       Elisha Barnes, pre-med, biology major, assisted Jessica Klopf                                (Medical School Applicant)                       Margaret Stire, biology major (Fall 05)                       Lanna Kuehler, biology major (Spring 06, collaboration w/ Dr. John O’Reilly)                       Wendy Boysha, biology major (Spring 06)                       Jameka Kemp, biology major (Summer 06, collaboration w/Dr. John O’Reilly)                       Charlie Golmon. biology major (Spring 07, Summer 07, Fall 07, Spring 08), STAR Grant Recipient                       Mindy Guidry, biology major (Fall 2007)                       Greg Landry, biology major (Spring 2008),                                 (LSU Health Sciences Center at Shrieveport, Ph.D. Program,                                       Department of Pharmacology, Toxicology, and Neuroscience)                       Christie Duvernay, biology major (Fall 2008, collaboration w/Dr. John O’Reilly)                                 (LSU Health Sciences Center, New Orleans, Med Tech. Certification Program)                       Janice Fan, pre-optometry, biology major (Fall 2008, collaboration w/Dr. John O’Reilly)                                 (Southern College of Optometry, Memphis TN.)                       Melissa Eddy, pre-med, biology major (Fall 2008, collaboration w/Dr. John O’Reilly)                       Meggie Doucet, pre-med, biology major, STAR Grant Recipient (Fall 2008-Spring 2008,                                collaboration with Dr. Nick Norton)                                 (LSU Medical School, Shreveport)                       Carolyn Rubin, pre-Vet/Ph.D., (Summer 2009, collaboration w/Dr. John O’Reilly)                                 (LSU Vet/Ph.D. Program)                       Adronisha Frazier, biology major, honors project (Fall 2009-Spring 2010)                                 (SLU Biology Graduate Program)                       Dana Mayer, pre-med, (Spring 2010, collaboration w/Dr. Robert Kraemer)                       Devin Champagne, chemistry major (Spring 2010, collaboration w/Dr. Robert Kraemer)                                 (SLU Biology Graduate Program)                       Bradley Bursavich, pre-med chemistry major,  (Spring 2010, collaboration w/Dr. Robert Kraemer)                                 (LSU Medical School)                       Jeremy Stagray, biology major (Spring 2010, collaboration w/Dr. Robert Kraemer)                       David Ward, pre-med, biology major (Spring/Sum 2010, collab. w/Dr. John O’Reilly)                                 (M.D./Ph.D. Program-LSU Medical School)                       Tricia Adams, biology major, (Fall 2010)                                  (LSU Department of Animal Sciences Ph.D. Program)                       Pramir K.C., biology major, (Spring/Fall 2011, Spring 2012)                       Jacob Delaune, biology major (Spring 2012, collaboration w/Dr. Robert Kraemer)                       Heather Robin, biology major (Spring 2012, collaboration w/Dr. Robert Kraemer)

-Graduate Students:                       Catherine diBenedetto-graduate student in biology (Masters Thesis Defended Jan 2004)                                 (Previously, Research Associate II,  Amgen, CA. and MannKind Corporation                                 (Diabetes and Cancer Research), Drug Discovery Department, Valencia, Ca.)                                 2007-present. Senior Scientist, Assay Development & Compound Profiling, Center for                                 Integrative Chemical Biology and Drug Discovery, University of North Carolina, Chapel Hill                       Charles Nebel, graduate student in biology (Non Thesis Masters Degree, Dec. 2005)                                (SLU and Delgato Community College part-time Instructor, Volunteer in Shockett Lab (Spring 2005)                       Erica Perrer, graduate student in biology, SLU graduate teaching scholarship recipient                                (Non-Thesis Masters Degree, Spring 2005)                                (Our Lady of the Lake College, Microbiology Lab Coordinator & Instructor)                                (Delgato Community College, Instructor)                       Jessica Mayfield, graduate student in biology                                (Non-Thesis Masters Degree, Spring 2006)(Instructor, SLU Biology Dept.)                       Jessica Klopf, graduate student in biology ((Non-Thesis Masters Degree, Spring 2006)                                 (Associate Scientist, Reliagene Technologies, Metarie LA.)                                 (Medical Research Technician, Dept. of Pharmacology, Tulane University Health Sciences Center)                       Rebecca Wallace, (Volunteer Fall 2004, Course Credit Spring 2005) (Non-Thesis Masters Degree, Spring 2007)                       Jessica Chancey, graduate student in biology, SLU Graduate School Fellowship Recipient                                 (Masters Thesis Defended, April 2008) (Co-advisor, Dr. John O'Reilly)                                 (University of Alabama at Birmingham, Cellular & Molecular Biology Ph.D. Program)                       Wallissa Lancelin, (Spring-Fall 2009)(Non Thesis Masters Degree, Fall 2009)                                 (University of Houston College of Optometry)                   Nancy Dardis (Spring 2010) (collaboration with Robert Kraemer) (Masters thesis Defended, Nov. 2011)                       Adronisha Frazier-Current                       Devin Champagne-Current

FUNDING:

2010-2013    NIH R15 Grant, National Institute for Allergy and Infectious Disease,                     “Spatiotemporal Comparison of Aberrant and Ectopic V(D)J Recombination Events in Vivo” ($195,195). 2009-2010    CONDUITS Grant, Southeastern Office of Research and Graduate Studies                      (Collaborator with Robert Kraemer) ($2000) 2009-2010    Teaching Enhancement Grant-Southeastern Faculty Excellence ($500) 2009-2010    Student Technology Fee-Southeastern Office of Technology, (Collaborator with Robert Kraemer ) ($4,133.60) 2008             CONDUITS Grant.  $535.00 Supported purchase/shipment of mouse grain-based diet containing tetracycline. 2008-2011    NIH AREA Grant, National Heart Lung and Blood Institute, "Role of Segment 6 in Heart Na Channel Slow                      Inactivation", Competitive Renewal, ($186,895 for three years) (Collaborator with J. O’Reilly) 2007-2008    LEAD Grant, Southeastern Louisiana University, "Proteomics at Southeastern and Beyond", ($15,288). 2007-2008    Faculty Development Grant, Southeastern Louisiana University,                      "Inducible RAG Transgenic Mice: A Tool for Analysis of Constraints on V(D)J Rearrangement                      in Primary Lymphocytes and Nonlymphoid Cells. I. A comparison of cellular signals that activate                      V(D)J accessibility and rearrangement in fetal vs. adult nonlymphoid cells.”                      (Continuation Request, $1,984 for 1 year) 2007             Southeastern Louisiana University Student Technology Fee Small Project Proposal:                     "New Sensor Board and Motor for the Molecular Immunology Laboratory Incubator" ($1,853) 2006             Southeastern Louisiana University Student Technology Fee Small Project Proposal:                      “Technology-based teaching and learning in biology”                       (J. Bossart, F. Campo, P. Shockett, R. Valverde) ($5,000) 2006-2007    Faculty Development Grant, Southeastern Louisiana University, "Validation of 2D Protein Gel                         Analysis of DNAPKcs Phosphorylation Targets During V(D)J Recombination" ($980) 2005-2008    NIH AREA Grant, National Heart Lung and Blood Institute, "Role of Segment 6 in Heart Na Channel Slow                         Inactivation", ($179,092 for three years) (Collaborator with J. O’Reilly) 2005             Southeastern Louisiana University Student Technology Fee Small Project Proposal:"Molecular Biology                       Technology for Neurobiology and Immunology Laboratories" (w/J. O'Reilly) ($4,432.40) 2005             Southeastern Louisiana University Student Technology Fee Small Project Proposal:                     "Enhanced Technology for Neurobiology and Immunology Laboratories" (w/J. O’Reilly) ($2,523) 2005             Southeastern Louisiana University Student Technology Fee Surplus Computer Proposal:                      For For 2 Pentium III computers with monitors and printers. 2005-2006   Faculty Development Grant, Southeastern Louisiana University, "Inducible RAG Transgenic Mice:                     A Tool for Analysis of constraints on V(D)J Rearrangement in Primary Lymphocytes and Nonlymphoid                     Cells. I. A comparison of cellular signals that activate V(D)J accessibility and rearrangement in fetal vs. adult                     nonlymphoid cells.” (Continuation Request, $1,310 for 1 year) 2004             SLU Student Technology Fee Small Project Proposal, "A white light conversion screen for visualization and                      documentation of proteins on polyacrylamide gels using the BioRad ChemiDoc system."  ($400) 2004             SLU Student Technology Fee Surplus Computer Proposal: For 2 Pentium III computers with monitors. 2004-2005   Faculty Development Grant, Southeastern Louisiana University, "Inducible RAG Transgenic Mice:                      A Tool for Analysis of Constraints on V(D)J Rearrangement in Primary Lymphocytes and Nonlymphoid                     Cells.  I.  A comparison of cellular signals that activate V(D)J accessibility and rearrangement in fetal vs. adult                     nonlymphoid cells. ($1,800). 2004-2006   EPA Western Lake Pontchartrain Basin Research Program,  "Are Polycyclic Aromatic Hydrocarbons                     Stressors for Lymphocyte Development or Activation in Frog Populations in Bayou Trepagnier?" ($100,000) 2002             Student Technology Fee Grant, Southeastern Louisiana University, "Biotechnology equipment for the new                      Biological Sciences classroom and laboratory building",  (w/C. Jackson) ($24,188). 2001             SLU Student Technology Fee Grant, "A Peltier Thermocycler for the Department of Biological Sciences"                      (P. Shockett, G.Howard, G. Childers, and C. Jackson) ($4,842). 2001-2004    Louisiana Board of Regents Support Fund Grant, Research Competitiveness Subprogram. "Role of DNA-                      dependent protein kinase catalytic subunit in coding end processing during V(D)J recombination."                       ($92,805 for 3 years) 2001-2002    Faculty Development Grant, Southeastern Louisiana University                      "Diversity of receptors in the immune system: Role of the DNA-dependent protein kinase catalytic subunit"                       ($1,960 for 1 year). 1995-1998    Postdoctoral Fellowship, Arthritis Foundation ($80,500 for 3 years) 1993-1995    Competitive Postdoctoral Traineeship, NIH Training Grant, Section of Immunobiology,                      Yale University School of Medicine 1979-1983    Magna Cum Laude in Biology, Student Advisor to the Biology Department,                      Bowdoin College, Brunswick, ME.

PUBLICATIONS:

(* denotes student author)

O'Reilly JP, and Shockett PE (2012) Time- and state-dependent effects of methanethiosulfonate ethylammonium (MTSEA) exposure differ between heart and skeletal muscle voltage-gated Na+ channels. Biochimica et Biophysica Acta – Biomembranes March 1818(3):443-447. Epub 2011 Dec 4.Pub Med Chancey J.H.*, Shockett, P.E., and O'Reilly, J.P. (2007).  Relative Resistance to Slow Inactivation of Human Cardiac Na+ Channel hNav1.5 is Reversed by Lysine or Glutamine Substitution at V930 in D2-S6. American Journal of Physiology: Cell Physiology Pub Med O’Reilly, J.P. and Shockett, P.E. Conformational Change in Segment 6 of Domain 2 in  Human Cardiac Na+ Channel hNav1.5 During Slow Inactivation (2006).  Biochem Biophys Res Commun  345:59-66. Pub Med Shockett, P. and Schatz, D. (2005). UNIT 20.8: Inducible Gene Expression Using an Autoregulatory, Tetracycline-Controlled System, in Current Protocols in Cell Biology John Wiley & Sons, Inc. Shockett, P., Zhou, S., Hong, X. and Schatz, D. (2004). Partial reconstitution of V(D)J rearrangement and lymphocyte development in RAG-deficient mice expressing inducible, tetracycline-regulated RAG transgenes.  Molecular Immunology 40: 813-829.  Pub Med Chen, J., Kelz, M., Zeng, G., Steffan, C., Shockett, P, Terwilliger, G., Schatz, D., and Nestler, E. (2002).  Inducible, Reversible Hair Loss in Transgenic Mice. Transgenic Research 11:241-247.  Pub Med Fugmann, S. D., Lee, A. I., Shockett, P. E., Villey, I.J., and Schatz, D.G. (2000).  The RAG Proteins and V(D)J Recombination: Complexes,    Ends, and Transposition. Annual Review of Immunology, 18: April 2000.  Pub Med Shockett, P. E. and Schatz, D. G.  (1999).  DNA hairpin opening mediated by the RAG1 and RAG2 proteins.  Molecular and Cellular Biology.  Vol 19, 4159-4166.  Pub Med Chen, J., Kelz, M., Zeng G., Sakai N., Steffen C., Shockett, P., Picciotto M., Duman, R.,  and Nestler, E. (1998).  Transgenic animals with inducible, targeted gene expression in the brain.  Molec. Pharm. 54, 495-503. Pub Med Shockett, P. and Schatz, D. (1998).  Inducible expression in mammalian cells using a tetracycline-regulated system.  In, Cells: A Laboratory Manual, Volume 1, Section 5, Systems for Protein Expression.  Cold Spring Harbor Laboratory Press. Shockett, P. and Schatz, D. (1997).  Inducible gene expression using an autoregulatory, tetracycline-controlled system.  Current Protocols in Molecular Biology.  Unit 16.2.1 Shockett, P. and Schatz, D. (1997). Switching on gene expression.  Nature Biotechnology 15, 221-223. . Shockett, P. and Schatz, D. (1996).  Diverse strategies for tetracycline-regulated inducible gene expression.  PNAS, USA 93, 5173-5176.  Pub Med Shockett, P., Difilippantonio, M., Hellman, N.* and Schatz, D. (1995).   A modified  tetracycline-regulated system provides autoregulatory, inducible gene expression in  cultured cells and transgenic mice.  PNAS, USA 92, 6522-6526. Pub Med Shockett, P. and Stavnezer, J. (1993).  Inhibitors of poly(ADP-ribose) polymerase increase antibody class switching.  J. Immunol.  151, 6962-6976. Pub Med Lin, Y. Shockett, P. and Stavnezer, J. (1992).  Regulation of transcription of the germline immunoglobulin alpha constant region gene.  Curr. Top. Microbiol. Immunol. 182, 157-165. Shockett, P. and Stavnezer, J. (1991).  Effect of cytokines on switching to IgA and alpha-germline transcripts in the B lymphoma I.29 mu:  Transforming growth factor-beta activates transcription of the unrearranged C-alpha gene.  J. Immunol. 147, 4374-4383.   Pub Med Lin, Y. Shockett, P. and Stavnezer, J. (1991).  Regulation of the antibody class switch to IgA.  Immunol. Res. 10:376-380. Stavnezer, J., Shockett, P., Lin, Y. Saikh, K. and Xu, M. (1990).  The I.29 mouse B cell lymphoma:  Regulation of the antibody class switch. In Cytokines. Basel, Karger, vol 3, 154-169.

PRESENTATIONS: Champagne, D. and Shockett P. (2012).  Spatiotemporal analysis of illegitimate V(D)J deletions in Notch1 and Bcl11b genes. American Association of Immunologists Annual Meeting, Boston, MA. Chancey, J, Shockett, P., and O’Reilly, J. (2007).  Lysine substitution at V930 in D2-S6 of hNav1.5 greatly enhances slow inactivation.  Annual Meeting of the Biophysical Society, Baltimore, Maryland. Shockett, P. (2004). Molecular Mechanisms Generating Lymphocyte Antigen Receptors,  Southeastern Louisiana University Biology Seminar Series. Shockett, P. (2004). Molecular Mechanisms Generating Lymphocyte Antigen Receptors,  University of Southern Mississippi, Biology Seminar Series. Shockett, P. and Schatz, D, (1999).  RAG-mediated opening of hairpin coding ends in vitro to generate P regions.  Workshop on V(D)J Recombination.  Keystone Symposium on B Lymphocyte Biology and Disease.   Taos, New Mexico. Shockett, P. and Schatz, D. (1999). DNA hairpin opening mediated by the RAG1 and RAG2 proteins.   Yale University Section of Immunobiology Retreat. June 1999. (and '98,'97,'96,'95,'94-various titles and authors) Shockett, P. and Schatz, D. (1996).  Construction of transgenic mice inducibly expressing the RAG genes.   Keystone Symposium on Lymphocyte Activation.  Hilton Head, South Carolina.   Shockett, P. and Schatz, D. (1995).  Construction of transgenic mice inducibly expressing the RAG genes.   Genetic Recombination & Genome Rearrangements.  FASEB Summer Conference, Snowmass, Colorado. Shockett, P. (1995). Characterization of a tetracycline-regulated system for inducible transgenic mice. The Dupont Merck Pharmaceutical Co.,  Experimental Station, Wilmington, Delaware, Robert Horlick, Host. Shockett, P. and Stavnezer, J. (1991).  Regulation of germline-α transcripts and switching in the I.29μ B-cell lymphoma.   FASEB summer research conference, Saxtons River,Vermont. Lin, Y., Shockett, P. and Stavnezer, J. (1990).  Regulation of Immunoglobulin α-germline transcripts prior to heavy chain switch in I.29μ cells.  New England Immunology Conference, Woods Hole Ma. Stavnezer, J., Shockett, P. and Severinson, E. (1989).  Effect of lymphokines on expression of RNAs transcribed from germline immunoglobulin heavy chain constant region genes in the I.29 B cell lymphoma.   7th International Congress of Immunology, Berlin. Shockett, P. and Woodland, B. (1988).  A unique B cell subpopulation in diabetes-prone BB/W  rats, absent in diabetes resistant sublines.  UCLA Symposia on Molecular and Cellular Biology, Symposium on B Cell Development (J. Cell  Biochem. Supp12B). Yearly Departmental Seminars: 1988-1992, Immunology & Virology Group, Univ. of Massachusetts, Grad. School of Biomed. Sci. 1994-1999. Section of Immunobiology, Yale Univ. School of Medicine.

PROFESSIONAL AFFILIATIONS and ACTIVITIES: American Association for the Advancement of Science http://www.AAAS.org/ American Association of Immunologistshttp://www.aai.org/ International Society of Developmental and Comparative Immunology http://www.isdci.org/ Reviewer for Journals: Journal of Immunology http://www.jimmunol.org/ Nature Biotechnology http://www.nature.com/nbt/ Nature Medicine  http://www.nature.com/nm/ Biotechnology Grant Reviewer: NSF Course, Curriculum, and Laboratory Improvement Interdisciplinary Grant Review Panels          (July 2001 & July 2002, Arlington, VA.)